Grey's Anatomy star Sandra Oh has shared her thoughts on a potential return to the show, and it's not good news.

Sandra is most recognised for her role as cardiothoracic surgeon Cristina Yang in the long-running medical drama.

Cristina was part of the original group of interns, alongside Meredith Grey (Ellen Pompeo), Alex Karev (Justin Chambers), Izzie Stevens (Katherine Heigl), and George O'Malley (TR Knight).

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During her tenure on the show, Cristina was at the centre of numerous high-profile storylines.

Her relationship with Preston Burke (Isaiah Washington) notably concluded on their wedding day in the third series, she was left shaken following the hospital shooting at the end of the sixth series, and was aboard the plane that crashed in the eighth series, reports the Mirror US.

After ten series, Cristina departed Grey Sloan Memorial Hospital for a job in Zurich, Switzerland. She took up a position at the Klausman Institute for Medical Research, a hospital established by her former mentor and ex-fiancé, Preston.

Since then, Sandra has starred in a variety of popular films and TV shows, including Killing Eve, The Chair and Turning Red.

More than a decade after her departure from Grey's Anatomy, fans are still holding out hope for Cristina's comeback. However, Sandra has now addressed the possibility, and it's not the news fans were hoping for.

In a chat with Deadline, the 53-year-old actress expressed appreciation for the show's fans, but also stated that she had "to be true" to herself.

"What I have noticed, this is ten years out from leaving the show, is the deep appreciation that I have for the people who appreciate Cristina," Sandra said.

"It is that love that has made me go, 'Oh, the fans really, really, really want it,' and for the first time, that's when I started opening up the idea."

However, she added: "For me, I think to really be true to the people who enjoy your work, you have to be true to yourself. So, at this point, I don't think so."

This sentiment echoes what Sandra expressed last year when probed about reprising her role as Cristina.

"I love that you asked me that, because Cristina Yang is, of course, near and dear to my heart. [But] I will say, not anytime soon, my love," she had previously shared with Entertainment Tonight.

"I hope people feel like I did my job, which is that I brought to life a character and she had a growth over ten seasons, and that it was true. She was ready to move on, and so have I."

The season 21 finale of Grey's Anatomy aired in May, culminating in a nail-biting cliffhanger as a mother threatened to blow up a gas tank unless Amelia Shepherd (Caterina Scorsone) performed surgery on her child.

The explosive conclusion left viewers on the edge of their seats, with the destinies of several characters up in the air. Fans are eagerly awaiting the premiere of season 22 later this year to discover the aftermath of the devastating blast.

Grey's Anatomy is available to stream on Disney+