Joe Rogan has sparked significant online discussion after revealing details about a medical procedure where plasma is extracted from his blood and replaced. He likened this process to "changing the oil" in a vehicle. In an Instagram post, Rogan shared a photo of himself with three bags filled with an orange-yellow liquid, which he identified as plasma. He explained that the procedure involves removing plasma that contains "inflammatory proteins, toxins, and byproducts" and substituting it to enhance the body's functionality. He stated, "It's essentially like changing the oil in your body." Rogan noted that while the procedure may seem unusual, those he knows who have undergone it reported improvements in sleep quality and recovery times.

The method he described resembles plasmapheresis, a medical treatment that removes plasma from the bloodstream and replaces it with other fluids. This treatment is typically reserved for specific autoimmune or neurological disorders rather than general wellness applications.